Led by RTI International, an independent nonprofit research institute dedicated to improving the human condition, the Substance Treatment Strategies for HIV care (STS4HIV) Project is dedicated to improving HIV care. During the project’s first three years, key stakeholders (e.g., clients/patients, staff, funders) from across the United States will participate in up to three interactive national surveys. The goal of the first interactive national survey is to identify substances that have the most negative impact on HIV. The goal of the second interactive national survey is to identify the treatments that are most promising for addressing the most negatively impactful substance use disorders. The goal of the third interactive national survey is to identify the strategies that are most promising for integrating the most promising treatments. During the project’s last two years, the project’s guiding coalition of stakeholders will finalize and nationally disseminate multiple “Substance Treatment Strategy (STS) recommendations” that will provide HIV service organizations and their staff with actionable steps to improve integration of substance use services within HIV service settings.